ABTEILUNG MIKROGRAVITATION UND TRANSLATIONALE REGENERATIVE MEDIZIN

Dr. rer. nat. Markus Wehland

AG-Leiter

Dr. rer. nat. Markus Wehland

Abteilung Mikrogravitation und Translationale Regenerative Medizin (MTRM)
AG Tissue Engineering & Translationale Regenerative Medizin
Universitätsplatz 2, 39106 Magdeburg, G28-010
Publikationen

2023

Begutachteter Zeitschriftenartikel

Sahana, Urjosee; Wehland, Markus; Simonsen, Ulf; Schulz, Herbert; Grimm, Daniela

A systematic review of the effect of vericiguat on patients with heart failure
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 14, Artikel 11826, insges. 18 S.

Begutachteter Zeitschriftenartikel

Sahana, Jayashree; Cortés-Sánchez, José Luis; Sandt, Viviann; Melnik, Daniela; Corydon, Thomas Juhl; Schulz, Herbert; Cai, Zexi; Evert, Katja; Grimm, Daniela; Wehland, Markus

Long-term simulation of microgravity induces changes in gene expression in breast cancer cells
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 2, Artikel 1181, insges. 23 S.

Begutachteter Zeitschriftenartikel

Jokšienė, Justina; Sahana, Jayashree; Wehland, Markus; Schulz, Herbert; Cortés-Sánchez, José Luis; Prat-Duran, Judit; Grimm, Daniela; Simonsen, Ulf

Effects of high glucose on human endothelial cells exposed to simulated microgravity
In: Biomolecules - Basel : MDPI, Bd. 13 (2023), Heft 2, Artikel 189, insges. 22 S.

Begutachteter Zeitschriftenartikel

Wang, Linnea Højer; Wehland, Markus; Wise, Petra; Infanger, Manfred; Grimm, Daniela; Kreißl, Michael

Cabozantinib, vandetanib, pralsetinib and selpercatinib as treatment for progressed medullary thyroid cancer with a main focus on hypertension as adverse effect
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 3, Artikel 2312, insges. 18 S.

Begutachteter Zeitschriftenartikel

Jensen, Niklas S.; Wehland, Markus; Wise, Petra; Grimm, Daniela

Latest knowledge on the role of vitamin D in hypertension
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 5, Artikel 4679, insges. 22 S.

Begutachteter Zeitschriftenartikel

Corydon, Thomas J.; Schulz, Herbert; Richter, Peter; Strauch, Sebastian M.; Böhmer, Maik; Ricciardi, Dario A.; Wehland, Markus; Krüger, Marcus; Erzinger, Gilmar S.; Lebert, Michael; Infanger, Manfred; Wise, Petra; Grimm, Daniela

Current knowledge about the impact of microgravity on gene regulation
In: Cells - Basel : MDPI, Bd. 12 (2023), Heft 7, Artikel 1043, insges. 59 S.

2022

Begutachteter Zeitschriftenartikel

Baran, Ronni; Marchal, Shannon; Campos, Sebastian Garcia; Rehnberg, Emil; Tabury, Kevin; Baselet, Bjorn; Wehland, Markus; Grimm, Daniela; Baatout, Sarah

The cardiovascular system in space - focus on in vivo and in vitro studies
In: Biomedicines - Basel : MDPI, Bd. 10 (2022), Heft 1, Artikel 59, insges. 29 S.

Begutachteter Zeitschriftenartikel

Schulz, Herbert; Strauch, Sebastian M.; Richter, Peter; Wehland, Markus; Krüger, Marcus; Sahana, Jayashree; Corydon, Thomas J.; Wise, Petra; Baran, Ronni; Lebert, Michael; Grimm, Daniela

Latest knowledge about changes in the proteome in microgravity
In: Expert review of proteomics - Abingdon : Taylor & Francis Group, Bd. 19 (2022), Heft 1, S. 43-59

Begutachteter Zeitschriftenartikel

Dietrichs, Dorothea; Grimm, Daniela; Sahana, Jayashree; Melnik, Daniela; Corydon, Thomas J.; Wehland, Markus; Krüger, Marcus; Vermeesen, Randy; Baselet, Bjorn; Baatout, Sarah; Hybel, Trine Engelbrecht; Kahlert, Stefan; Schulz, Herbert; Infanger, Manfred; Kopp, Sascha

Three-dimensional growth of prostate cancer cells exposed to simulated microgravity
In: Frontiers in cell and developmental biology - Lausanne : Frontiers Media, Bd. 10 (2022), Artikel 841017, insges. 21 S.

Begutachteter Zeitschriftenartikel

Grimm, Daniela; Schulz, Herbert; Krüger, Marcus; Cortés-Sánchez, José Luis; Egli, Marcel; Kraus, Armin; Sahana, Jayashree; Corydon, Thomas J.; Hemmersbach, Ruth; Wise, Petra; Infanger, Manfred; Wehland, Markus

The fight against cancer by microgravity - the multicellular spheroid as a metastasis model
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 23 (2022), Heft 6, Artikel 3073, insges. 45 S.

Begutachteter Zeitschriftenartikel

Schulz, Herbert; Dietrichs, Dorothea; Wehland, Markus; Corydon, Thomas J.; Hemmersbach, Ruth; Liemersdorf, Christian; Melnik, Daniela; Hübner, Norbert; Saar, Kathrin; Infanger, Manfred; Grimm, Daniela

In prostate cancer cells cytokines are early responders to gravitational changes occurring in parabolic flights
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 14, insges. 18 S.

Begutachteter Zeitschriftenartikel

Baran, Ronni; Wehland, Markus; Schulz, Herbert; Heer, Martina; Infanger, Manfred; Grimm, Daniela

Microgravity-related changes in bone density and treatment options - a systematic review
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 15, insges. 23 S.

Begutachteter Zeitschriftenartikel

Hansen, Emma; Grimm, Daniela; Wehland, Markus

Current knowledge about the new drug firibastat in arterial hypertension
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 23 (2022), Heft 3, Artikel 1459, insges. 13 S.

2021

Begutachteter Zeitschriftenartikel

Baran, Ronni; Grimm, Daniela Gabriele; Infanger, Manfred; Wehland, Markus

The effect of continuous positive airway pressure therapy on obstructive sleep apnea-related hypertension
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 5, insges. 14 S.

Begutachteter Zeitschriftenartikel

Wise, Petra; Neviani, Paolo; Riwaldt, Stefan; Corydon, Thomas J.; Wehland, Markus; Braun, Markus; Krüger, Marcus; Infanger, Manfred; Grimm, Daniela Gabriele

Changes in exosomal miRNA composition in thyroid cancer cells after prolonged exposure to real microgravity in space
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 23, insges. 24 S.

Begutachteter Zeitschriftenartikel

Kaae, Anne Christine; Kreißl, Michael; Krüger, Marcus; Infanger, Manfred; Grimm, Daniela Gabriele; Wehland, Markus

Kinase-inhibitors in iodine-refractory differentiated thyroid cancer - focus on occurrence, mechanisms, and management of treatment-related hypertension
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 22, insges. 23 S.

Begutachteter Zeitschriftenartikel

Melnik, Daniela; Krüger, Marcus; Schulz, Herbert; Kopp, Sascha; Wehland, Markus; Bauer, Johann; Baselet, Bjorn; Vermeesen, Randy; Baatout, Sarah; Corydon, Thomas J.; Infanger, Manfred; Grimm, Daniela Gabriele

The CellBox-2 Mission to the International Space Station - thyroid cancer cells in space
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 16, insges. 21 S.

Begutachteter Zeitschriftenartikel

Riwaldt, Stefan; Corydon, Thomas J.; Pantalone, Desiré; Sahana, Jayashree; Wise, Petra; Wehland, Markus; Krüger, Marcus; Melnik, Daniela; Kopp, Sascha; Infanger, Manfred; Grimm, Daniela

Role of apoptosis in wound healing and apoptosis alterations in microgravity
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, 2013, Bd. 9 (2021), insges. 22 S.

Begutachteter Zeitschriftenartikel

Sahana, Jayashree; Corydon, Thomas J.; Wehland, Markus; Krüger, Marcus; Kopp, Sascha; Melnik, Daniela; Kahlert, Stefan; Relja, Borna; Infanger, Manfred; Grimm, Daniela Gabriele

Alterations of growth and focal adhesion molecules in human breast cancer cells exposed to the random positioning machine
In: Frontiers in cell and developmental biology - Lausanne: Frontiers Media, 2013, Bd. 9 (2021), insges. 17 S.

Begutachteter Zeitschriftenartikel

Ravichandran, Briyanth; Grimm, Daniela Gabriele; Krüger, Marcus; Kopp, Sascha; Infanger, Manfred; Wehland, Markus

SARS-CoV-2 and hypertension
In: Physiological reports - [S.l.]: Wiley, 2013, Bd. 9 (2021), insges. 14 S.

Begutachteter Zeitschriftenartikel

Wise, Petra; Neviani, Paolo; Riwaldt, Stefan; Corydon, Thomas Juhl; Wehland, Markus; Braun, Markus; Krüger, Marcus; Infanger, Manfred; Grimm, Daniela

Changes in exosome release in thyroid cancer cells after prolonged exposure to real microgravity in space
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 4, insges. 19 S.

2020

Begutachteter Zeitschriftenartikel

Ancker, Ole Vincent; Krüger, Marcus; Wehland, Markus; Infanger, Manfred; Grimm, Daniela Gabriele

Multikinase inhibitor treatment in thyroid cancer
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 1, Art.-Nr. 10, insges. 19 Seiten

Begutachteter Zeitschriftenartikel

Grimm, Daniela Gabriele; Bauer, Johann; Wise, Petra; Krüger, Marcus; Simonsen, Ulf; Wehland, Markus; Infanger, Manfred; Corydon, Thomas J.

The role of SOX family members in solid tumours and metastasis
In: Seminars in cancer biology - London: Academic Press, 1995, Bd. 67 (2020), 1, S. 122-153, 2019

Begutachteter Zeitschriftenartikel

Lützenberg, Ronald; Burg, Doris; Grimm, Daniela Gabriele; Wehland, Markus; Infanger, Manfred

Selective surgical treatment of the intraneural perineurioma of the femoral nerve by tumor resection and graft repair
In: Journal of case reports and medical images - Reno, NV: MedDocs Publishers LLC, 2018, Vol. 3.2020, 1, 1060, 5 Seiten

Begutachteter Zeitschriftenartikel

Wehland, Markus; Steinwerth, Paul; Aleshcheva, Ganna; Sahana, Jayashree; Hemmersbach, Ruth; Lützenberg, Ronald; Kopp, Sascha; Infanger, Manfred; Grimm, Daniela

Tissue engineering of cartilage using a random positioning machine
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International - Vol. 21.2020, 24, 9596, insgesamt 24 Seiten

Begutachteter Zeitschriftenartikel

Nassef, Mohamed Zakaria; Melnik, Daniela; Kopp, Sascha; Sahana, Jayashree; Infanger, Manfred; Lützenberg, Ronald; Relja, Borna; Wehland, Markus; Grimm, Daniela; Krüger, Marcus

Breast cancer cells in microgravity - new aspects for cancer research
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 19, Art.-Nr. 7345, insges. 22 Seiten

Begutachteter Zeitschriftenartikel

Krüger, Marcus; Kopp, Sascha; Wehland, Markus; Corydon, Thomas J.; Grimm, Daniela Gabriele

Science between bioreactors and space research - response to comments by Joseph J. Bevelacqua et al. on Dexamethasone Inhibits Spheroid Formation of Thyroid Cancer Cells Exposed to Simulated Microgravity
In: Cells - Basel: MDPI, 2012, Vol. 9.2020, 8, Art.-Nr. 1763, insges. 3 Seiten

Begutachteter Zeitschriftenartikel

Grimm, Daniela Gabriele; Wehland, Markus; Corydon, Thomas J.; Richter, Peter; Prasad, Binod; Bauer, Johann; Egli, Marcel; Kopp, Sascha; Lebert, Michael; Krüger, Marcus

The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells
In: Stem cells translational medicine - Durham: AlphaMed Press, 2012, Bd. 9 (2020), 8, S. 882-894

Begutachteter Zeitschriftenartikel

Bauer, Thomas J.; Gombocz, Erich; Wehland, Markus; Bauer, Johann; Infanger, Manfred; Grimm, Daniela Gabriele

Insight in adhesion protein sialylation and microgravity dependent cell adhesion - an omics network approach
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 5, Art.-Nr. 1749, insges. 23 Seiten

Begutachteter Zeitschriftenartikel

Enevoldsen, Frederik C.; Sahana, Jayashree; Wehland, Markus; Grimm, Daniela; Infanger, Manfred; Krüger, Marcus

Endothelin receptor antagonists - status quo and future perspectives for targeted therapy
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd. 9.2020, 3, Art.-Nr. 824, insges. 29 Seiten

Begutachteter Zeitschriftenartikel

Wehland, Markus; Simonsen, Ulf; Buus, Niels Henrik; Krüger, Marcus; Grimm, Daniela Gabriele

An evaluation of the fixed-dose combination sacubitril/valsartan for the treatment of arterial hypertension
In: Expert opinion on pharmacotherapy - Abingdon, Oxon: Routledge, Taylor & Francis, Bd. 21 (2020), 10, S. 1133-1143

Begutachteter Zeitschriftenartikel

Hybel, Trine Engelbrecht; Dietrichs, Dorothea; Sahana, Jayashree; Corydon, Thomas J.; Nassef, Mohamed Zakaria; Wehland, Markus; Krüger, Marcus; Magnusson, Nils E.; Bauer, Johann; Utpatel, Kirsten; Infanger, Manfred; Grimm, Daniela; Kopp, Sascha

Simulated microgravity influences VEGF, MAPK, and PAM signaling in prostate cancer cells
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 4, Art.-Nr. 1263, insges. 26 Seiten

Begutachteter Zeitschriftenartikel

Melnik, Daniela; Sahana, Jayashree; Corydon, Thomas J.; Kopp, Sascha; Nassef, Mohamed Zakaria; Wehland, Markus; Infanger, Manfred; Grimm, Daniela; Krüger, Marcus

Dexamethasone inhibits spheroid formation of thyroid cancer cells exposed to simulated microgravity
In: Cells - Basel: MDPI, 2012, Vol. 9.2020, 2, Art.-Nr. 367, insges. 25 Seiten

Begutachteter Zeitschriftenartikel

Povlsen, Amalie L.; Grimm, Daniela Gabriele; Wehland, Markus; Infanger, Manfred; Krüger, Marcus

The vasoactive mas receptor in essential hypertension
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd. 9.2020, 1, Art.-Nr. 267, insges. 12 Seiten

Begutachteter Zeitschriftenartikel

Legarth, Christian; Grimm, Daniela; Krüger, Marcus; Infanger, Manfred; Wehland, Markus

Potential beneficial effects of vitamin D in coronary artery disease
In: Nutrients - Basel: MDPI, 2009, Vol.12.2020, 1, Art.-Nr. 99, insges. 22 Seiten

Begutachteter Zeitschriftenartikel

Strube, Florian; Infanger, Manfred; Wehland, Markus; Delvinioti, Xenia; Romswinkel, Alexander; Dietz, Carlo; Kraus, Armin

Alteration of cytoskeleton morphology and gene expression in human breast cancer cells under simulated microgravity
In: Cell journal (Yakhteh) - [S.l.]: Inst., 2011, Bd. 22 (2020), 1, S. 106-114

Begutachteter Zeitschriftenartikel

Lindegaard Pedersen, Mia; Krüger, Marcus; Grimm, Daniela Gabriele; Infanger, Manfred; Wehland, Markus

The prostacyclin analogue treprostinil in the treatment of pulmonary arterial hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 126 (2020), 1, S. 32-42

2019

Abstract

Nassef, Mohamed Z.; Kopp, Sascha; Melnik, Daniela; Krüger, Marcus; Wehland, Markus; Corydon, Thomas J.; Bauer, Johann; Infanger, Manfred; Grimm, Daniela Gabriele

Alterations of the cytoskeleton in breast cancer cells during microgravity visualised by FLUMIAS live-cell imaging
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, 2007, Bd. 10.2019, Abstract 8, insges. 3 S.

Abstract

Kopp, Sascha; Krüger, Marcus; Wehland, Markus; Bauer, Johann; Dittrich, Anita; Infanger, Manfred; Grimm, Daniela Gabriele

Growing tissues in space
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, 2007, Bd. 10.2019, Abstract 14, insges. 3 S.

Abstract

Melnik, Daniela; Krüger, Marcus; Kopp, Sascha; Wehland, Markus; Bauer, Johann; Infanger, Manfred; Grimm, Daniela Gabriele

Microgravity-based modulation of VEGF expression in human thyroid carcinoma cells
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, 2007, Bd. 10.2019, Abstract 2, insges. 4 S.

Begutachteter Zeitschriftenartikel

Buken, Christoph; Sahana, Jayashree; Corydon, Thomas J.; Melnik, Daniela; Bauer, Johann; Wehland, Markus; Krüger, Marcus; Balk, Silke; Abuagela, Nauras; Infanger, Manfred; Grimm, Daniela Gabriele

Morphological and molecular changes in juvenile normal human fibroblasts exposed to simulated microgravity
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 9.2019, Art.-Nr. 11882, insges. 22 S.

Begutachteter Zeitschriftenartikel

Nassef, Mohamed Zakaria; Kopp, Sascha; Wehland, Markus; Melnik, Daniela; Sahana, Jayashree; Krüger, Marcus; Corydon, Thomas J.; Oltmann, Hergen; Schmitz, Burkhard; Schütte, Andreas; Bauer, Thomas J.; Infanger, Manfred; Grimm, Daniela Gabriele

Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 13, Art.-Nr. 3156, insges. 25 S.

Begutachteter Zeitschriftenartikel

Toxvig, Anne Kathrine; Wehland, Markus; Grimm, Daniela Gabriele; Infanger, Manfred; Krüger, Marcus

A focus on riociguat in the treatment of pulmonary arterial hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 125 (2019), 3, S. 202-214

Begutachteter Zeitschriftenartikel

Krüger, Marcus; Melnik, Daniela; Kopp, Sascha; Buken, Christoph; Sahana, Jayashree; Bauer, Johann; Wehland, Markus; Hemmersbach, Ruth; Corydon, Thomas J.; Infanger, Manfred; Grimm, Daniela Gabriele

Fighting thyroid cancer with microgravity research
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 10, Art.-Nr. 2553, insges. 21 S.

Begutachteter Zeitschriftenartikel

Olawi, Nasima; Krüger, Marcus; Grimm, Daniela Gabriele; Infanger, Manfred; Wehland, Markus

Nebivolol in the treatment of arterial hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 125 (2019), 3, S. 189-201

Begutachteter Zeitschriftenartikel

Krüger, Marcus; Pietsch, Jessica; Bauer, Johann; Kopp, Sascha; Carvalho, Daniel T. O.; Baatout, Sarah; Moreels, Marjan; Melnik, Daniela; Wehland, Markus; Egli, Marcel; Sahana, Jayashree; Kobberø, Sara Dam; Corydon, Thomas J.; Nebuloni, Stefano; Gass, Samuel; Evert, Matthias; Infanger, Manfred; Grimm, Daniela Gabriele

Growth of endothelial cells in space and in simulated microgravity - a comparison on the secretory level
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 52 (2019), 5, S. 1039-1060

Begutachteter Zeitschriftenartikel

Krüger, Marcus; Kopp, Sascha; Wehland, Markus; Bauer, Johann; Baatout, Sarah; Moreels, Marjan; Egli, Marcel; Corydon, Thomas J.; Infanger, Manfred; Grimm, Daniela Gabriele

Growing blood vessels in space - preparation studies of the SPHEROIDS project using related ground-based studies
In: Acta astronautica - Amsterdam [u.a.]: Elsevier Science, Bd. 159 (2019), S. 267-272

Begutachteter Zeitschriftenartikel

Mann, Vivek; Grimm, Daniela Gabriele; Corydon, Thomas J.; Krüger, Marcus; Wehland, Markus; Riwaldt, Stefan; Sahana, Jayashree; Kopp, Sascha; Bauer, Johann; Reseland, Janne E.; Infanger, Manfred; Lian, Aina Mari; Okoro, Elvis; Sundaresan, Alamelu

Changes in human foetal osteoblasts exposed to the random positioning machine and bone construct tissue engineering
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 6, Art.-Nr. 1357, insges. 26 S.

Begutachteter Zeitschriftenartikel

Budolfsen, Cecilie; Faber, Julie; Grimm, Daniela Gabriele; Krüger, Marcus; Bauer, Johann; Wehland, Markus; Infanger, Manfred; Magnusson, Nils Erik

Tyrosine kinase inhibitor-induced hypertension - role of hypertension as a biomarker in cancer treatment
In: Current vascular pharmacology - Hilversum [u.a.]: Bentham Science Publ., Bd. 17 (2019), 6, S. 618-634

Begutachteter Zeitschriftenartikel

Khalaf, David; Krüger, Marcus; Wehland, Markus; Infanger, Manfred; Grimm, Daniela Gabriele

The effects of oral L-arginine and L-citrulline supplementation on blood pressure
In: Nutrients - Basel: MDPI, 2009, Bd. 11.2019, 7, Art.-Nr. 1679, insges. 14 S.

Begutachteter Zeitschriftenartikel

Lützenberg, Ronald; Wehland, Markus; Solano, Kendrick; Nassef, Mohamed Z.; Buken, Christoph; Melnik, Daniela; Bauer, Johann; Kopp, Sascha; Krüger, Marcus; Riwaldt, Stefan; Hemmersbach, Ruth; Schulz, Herbert; Infanger, Manfred; Grimm, Daniela

Beneficial effects of low frequency vibration on human chondrocytes in vitro
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 53 (2019), Heft 4, S. 623-637

Begutachteter Zeitschriftenartikel

Nassef, Mohamed Zakaria; Kopp, Sascha; Melnik, Daniela; Corydon, Thomas J.; Sahana, Jayashree; Krüger, Marcus; Wehland, Markus; Bauer, Thomas J.; Liemersdorf, Christian; Hemmersbach, Ruth; Infanger, Manfred; Grimm, Daniela

Short-term microgravity influences cell adhesion in human breast cancer cells
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 22, Art.-Nr. 5730, insges. 27 Seiten

Begutachteter Zeitschriftenartikel

Deutch, Mikkel R.; Grimm, Daniela; Wehland, Markus; Infanger, Manfred; Krüger, Marcus

Bioactive candy - effects of licorice on the cardiovascular system
In: Foods - Basel: MDPI, 2012, Bd.8.2019, 10, Art.-Nr. 495, insges. 20 Seiten

Begutachteter Zeitschriftenartikel

Møller, Nanna Bæk; Budolfsen, Cecilie; Grimm, Daniela Gabriele; Krüger, Marcus; Infanger, Manfred; Wehland, Markus; Magnusson, Nils E.

Drug-induced hypertension caused by multikinase inhibitors (sorafenib, sunitinib, lenvatinib and axitinib) in renal cell carcinoma treatment
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd.20.2019, 19, Art.-Nr. 4712, insges. 23 Seiten

2018

Begutachteter Zeitschriftenartikel

Kopp, Sascha; Krüger, Marcus; Bauer, Johann; Wehland, Markus; Corydon, Thomas J.; Sahana, Jayashree; Nassef, Mohamed Zakaria; Melnik, Daniela; Bauer, Thomas J.; Schulz, Herbert; Schütte, Andreas; Schmitz, Burkhard; Oltmann, Hergen; Feldmann, Stefan; Infanger, Manfred; Grimm, Daniela Gabriele

Microgravity affects thyroid cancer cells during the TEXUS-53 mission stronger than hypergravity
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 12, Art.-Nr. 4001, insges. 20 S.

Begutachteter Zeitschriftenartikel

Nielsen, Peter Munch; Grimm, Daniela Gabriele; Wehland, Markus; Simonsen, Ulf; Krüger, Marcus

The combination of valsartan and sacubitril in the treatment of hypertension and heart failure - an update
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 122 (2018), 1, S. 9-18

Begutachteter Zeitschriftenartikel

Legarth, Christian; Grimm, Daniela Gabriele; Wehland, Markus; Bauer, Johann; Krüger, Marcus

The impact of vitamin D in the treatment of essential hypertension
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 2, Art.-Nr. 455, insges. 14 S.

Begutachteter Zeitschriftenartikel

Kopp, Sascha; Sahana, Jayashree; Islam, Tawhidul; Petersen, Asbjørn Graver; Bauer, Johann; Corydon, Thomas J.; Schulz, Herbert; Saar, Kathrin; Hübner, Norbert; Slumstrup, Lasse; Riwaldt, Stefan; Wehland, Markus; Infanger, Manfred; Luetzenberg, Ronald; Grimm, Daniela Gabriele

The role of NF[kappa]B in spheroid formation of human breast cancer cells cultured on the Random Positioning Machine
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 8.2018, Art.-Nr. 921, insges. 17 S.

Begutachteter Zeitschriftenartikel

Kopp, Sascha; Krüger, Marcus; Feldmann, Stefan; Oltmann, Hergen; Schütte, Andreas; Schmitz, Burkhard; Bauer, Johann; Schulz, Herbert; Saar, Kathrin; Hübner, Norbert; Wehland, Markus; Nassef, Mohamed Zakaria; Melnik, Daniela; Meltendorf, Stefan; Infanger, Manfred; Grimm, Daniela

Thyroid cancer cells in space during the TEXUS-53 sounding rocket mission - the THYROID project
In: Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature - Bd. 8.2018, Art.-Nr. 10355, insges. 13 S.

Begutachteter Zeitschriftenartikel

Sahana, Jayashree; Nassef, Mohamed Zakaria; Wehland, Markus; Kopp, Sascha; Krüger, Marcus; Corydon, Thomas J.; Infanger, Manfred; Bauer, Johann; Grimm, Daniela Gabriele

Decreased E-cadherin in MCF7 human breast cancer cells forming multicellular spheroids exposed to simulated microgravity
In: Proteomics - Weinheim: Wiley VCH, Bd. 18.2018, 13, Art.-Nr. e1800015

Begutachteter Zeitschriftenartikel

Lützenberg, Ronald; Solano, Kendrick; Buken, Christoph; Sahana, Jayashree; Riwaldt, Stefan; Kopp, Sascha; Krüger, Marcus; Schulz, Herbert; Saar, Kathrin; Hübner, Norbert; Hemmersbach, Ruth; Bauer, Johann; Infanger, Manfred; Grimm, Daniela Gabriele; Wehland, Markus

Pathway analysis hints towards beneficial effects of long-term vibration on human chondrocytes
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 47 (2018), 4, S. 1729-1741

Begutachteter Zeitschriftenartikel

Bauer, Johann; Wehland, Markus; Infanger, Manfred; Grimm, Daniela Gabriele; Gombocz, Erich

Semantic analysis of posttranslational modification of proteins accumulated in thyroid cancer cells exposed to simulated microgravity
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 8, Art.-Nr. 2257, insges. 16 S.

Begutachteter Zeitschriftenartikel

Bedan, Martin; Grimm, Daniela Gabriele; Wehland, Markus; Simonsen, Ulf; Infanger, Manfred; Krüger, Marcus

A focus on macitentan in the treatment of pulmonary arterial hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 123 (2018), 2, S. 103-113

Begutachteter Zeitschriftenartikel

Milling, Rikke Vilsbøll; Grimm, Daniela Gabriele; Krüger, Marcus; Grosse, Jirka; Kopp, Sascha; Bauer, Johann; Infanger, Manfred; Wehland, Markus

Pazopanib, cabozantinib, and vandetanib in the treatment of progressive medullary thyroid cancer with a special focus on the adverse effects on hypertension
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 10, Art.-Nr. 3258, insges. 15 S.

Begutachteter Zeitschriftenartikel

Grimm, Daniela Gabriele; Egli, Marcel; Krüger, Marcus; Riwaldt, Stefan; Corydon, Thomas J.; Kopp, Sascha; Wehland, Markus; Wise, Petra; Infanger, Manfred; Mann, Vivek; Sundaresan, Alamelu

Tissue engineering under microgravity conditions - use of stem cells and specialized cells
In: Stem Cells and Development - Larchmont, NY: Liebert, Bd. 27 (2018), 12, S. 787-804

Begutachteter Zeitschriftenartikel

Kraus, Armin; Sattler, Daniel; Wehland, Markus; Luetzenberg, Ronald; Abuagela, Nauras; Infanger, Manfred

Vascular endothelial growth factor enhances proliferation of human tenocytes and promotes tenogenic gene expression
In: Plastic and reconstructive surgery - Philadelphia, Pa.: Lippincott Williams & Wilkins, Bd. 142 (2018), 5, S. 1240-1247

2017

Abstract

Kraus, Armin; Dietz, Carlo; Wehland, Markus; Infanger, Manfred; Lützenberg, Ronald

Scaffold-freies 3D-Zellkulturmodell humaner Lungenkarzinomzellen unter simulierter Mikrogravitation
In: Zentralblatt für Chirurgie - Stuttgart [u.a.]: Thieme, 2000, Bd. 142.2017, S01, insges. 1 S.

Buchbeitrag

Wehland, Markus; Grimm, Daniela

Tissue engineering in microgravity
In: Biotechnology in Space - Cham: Springer, 2017 . - 2017, S. 73-85

Begutachteter Zeitschriftenartikel

Bendtsen, Mathias Alrø Fichtner; Grimm, Daniela; Bauer, Johann; Wehland, Markus; Wise, Petra; Magnusson, Nils E.; Infanger, Manfred; Krüger, Marcus

Hypertension caused by lenvatinib and everolimus in the treatment of metastatic renal cell carcinoma
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 8, Art.-Nr. 1736, insges. 12 S.

Begutachteter Zeitschriftenartikel

Warnke, Elisabeth; Pietsch, Jessica; Kopp, Sascha; Bauer, Johann; Sahana, Jayashree; Wehland, Markus; Krüger, Marcus; Hemmersbach, Ruth; Infanger, Manfred; Lützenberg, Ronald; Grimm, Daniela

Cytokine release and focal adhesion proteins in normal thyroid cells cultured on the random positioning machine
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 43.2017, 1, S. 257-270

Begutachteter Zeitschriftenartikel

Bauer, Johann; Kopp, Sascha; Schlagberger, Elisabeth Maria; Grosse, Jirka; Sahana, Jayashree; Riwaldt, Stefan; Wehland, Markus; Luetzenberg, Ronald; Infanger, Manfred; Grimm, Daniela

Proteome analysis of human follicular thyroid cancer cells exposed to the random positioning machine
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 3, Art.-Nr. 546, insges. 13 S.

Begutachteter Zeitschriftenartikel

Sørensen, Louise Marqvard; Wehland, Markus; Krüger, Marcus; Simonsen, Ulf; Nassef, Mohamed Zakaria; Infanger, Manfred; Grimm, Daniela

A special focus on selexipag - treatment of pulmonary arterial hypertension
In: Current pharmaceutical design: dispatches from the front line of drug design - Hilversum: Bentham Science Publ., 2000, Bd. 23.2017, 34, S. 5191-5199

Begutachteter Zeitschriftenartikel

Riwaldt, Stefan; Monici, Monica; Petersen, Asbjørn Graver; Jensen, Uffe Birk; Evert, Katja; Pantalone, Desiré; Utpatel, Kirsten; Evert, Matthias; Wehland, Markus; Krüger, Marcus; Kopp, Sascha; Frandsen, Sofie; Corydon, Thomas; Sahana, Jayashree; Bauer, Johann; Lützenberg, Ronald; Infanger, Manfred; Grimm, Daniela

Preparation of A spaceflight - apoptosis search in sutured wound healing models
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 12, Art.-Nr. 2604, insges. 22 S.

Begutachteter Zeitschriftenartikel

Hjermitslev, Marie; Grimm, Daniela G.; Wehland, Markus; Simonsen, Ulf; Krüger, Marcus

Azilsartan medoxomil, an angiotensin II receptor antagonist for the treatment of hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, 2004, Bd. 121.2017, 4, S. 225-233

Begutachteter Zeitschriftenartikel

Ancker, Ole Vincent; Wehland, Markus; Bauer, Johann; Infanger, Manfred; Grimm, Daniela

The adverse effect of hypertension in the treatment of thyroid cancer with multi-kinase inhibitors
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 3, Art.-Nr. 625, insges. 19 S.

2016

Begutachteter Zeitschriftenartikel

Andersen, Mathilde Borring; Simonsen, Ulf; Wehland, Markus; Pietsch, Jessica; Grimm, Daniela

LCZ696 (valsartan/sacubitril) - a possible new treatment for hypertension and heart failure
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, 2004, Bd. 118.2016, 1, S. 14-22

Begutachteter Zeitschriftenartikel

Aleshcheva, Ganna; Bauer, Johann; Hemmersbach, Ruth; Egli, Marcel; Wehland, Markus; Grimm, Daniela

Tissue engineering of cartilage on ground-based facilities
In: Microgravity science and technology: international journal for microgravity research and applications - Heidelberg: Springer, 2007, Bd. 28.2016, 3, S. 237-245

Begutachteter Zeitschriftenartikel

Bauer, Johann; Wehland, Markus; Pietsch, Jessica; Sickmann, Albert; Weber, Gerhard; Grimm, Daniela

Annotated gene and proteome data support recognition of interconnections between the results of different experiments in space research
In: Microgravity science and technology - Heidelberg: Springer, 2007, Bd. 28.2016, 3, S. 357-365

Begutachteter Zeitschriftenartikel

Corydon, Thomas J.; Kopp, Sascha; Wehland, Markus; Braun, Markus; Schütte, Andreas; Mayer, Tobias; Hülsing, Thomas; Oltmann, Hergen; Schmitz, Burkhard; Hemmersbach, Ruth; Grimm, Daniela

Alterations of the cytoskeleton in human cells in space proved by life-cell imaging
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 6.2016, Art.-Nr. 20043, insges. 14 S.

Begutachteter Zeitschriftenartikel

Kopp, Sascha; Slumstrup, Lasse; Corydon, Thomas J.; Sahana, Jayashree; Aleshcheva, Ganna; Islam, Tawhidul; Magnusson, Nils E.; Wehland, Markus; Bauer, Johann; Infanger, Manfred; Grimm, Daniela

Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 6.2016, Art.-Nr. 26887, insges. 18 S.

Begutachteter Zeitschriftenartikel

Riwaldt, Stefan; Bauer, Johann; Wehland, Markus; Slumstrup, Lasse; Kopp, Sascha; Warnke, Elisabeth; Dittrich, Anita; Magnusson, Nils E.; Pietsch, Jessica; Corydon, Thomas J.; Infanger, Manfred; Grimm, Daniela

Pathways regulating spheroid formation of human follicular thyroid cancer cells under simulated microgravity conditions - A genetic approach
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 17 (2016), 4, Art.-Nr. 528, insges. 20 S.

Begutachteter Zeitschriftenartikel

Laursen, Rasmus; Wehland, Markus; Kopp, Sascha; Pietsch, Jessica; Infanger, Manfred; Grosse, Jirka; Grimm, Daniela

Effects and role of multikinase inhibitors in thyroid cancer
In: Current pharmaceutical design - Hilversum: Bentham Science Publ, 2000, Bd. 22.2016, 39, S. 5915-5926

Begutachteter Zeitschriftenartikel

Grimm, Daniela; Grosse, Jirka; Wehland, Markus; Mann, Vivek; Reseland, Janne Elin; Sundaresan, Alamelu; Corydon, Thomas Juhl

The impact of microgravity on bone in humans
In: Bone: cell molecular biology, pathophysiology, treatment ; official journal of the International Bone and Mineral Society - Amsterdam [u.a.]: Elsevier Science, 1985, Bd. 87.2016, S. 44-56

Begutachteter Zeitschriftenartikel

Frandsen, Sofie; Kopp, Sascha; Wehland, Markus; Pietsch, Jessica; Infanger, Manfred; Grimm, Daniela

Latest results for anti-angiogenic drugs in cancer treatment
In: Current pharmaceutical design - Hilversum: Bentham Science Publ, 2000, Bd. 22.2016, 39, S. 5927-5942

Begutachteter Zeitschriftenartikel

Faensen, Anne Lena; Wehland-von Trebra, Markus; Freese, Florian; Kreutz, Reinhold; Bamberg, Christian; Hinkson, Larry; Rothermund, Lars

Genetic low nephron number hypertension is associated with altered expression of key components of the renin-angiotensin system during nephrogenesis
In: Journal of perinatal medicine - Berlin [u.a.]: de Gruyter, 1973, Bd. 44.2016, 6, S. 705-709

Begutachteter Zeitschriftenartikel

Warnke, Elisabeth; Kopp, Sascha; Wehland, Markus; Hemmersbach, Ruth; Bauer, Johann; Pietsch, Jessica; Infanger, Manfred; Grimm, Daniela

Thyroid cells exposed to simulated microgravity conditions - comparison of the fast rotating clinostat and the random positioning machine
In: Microgravity science and technology - Heidelberg: Springer, 2007, Bd. 28.2016, 3, S. 247-260

Begutachteter Zeitschriftenartikel

Wehland, Markus; Warnke, Elisabeth; Frett, Timo; Hemmersbach, Ruth; Hauslage, Jens; Ma, Xiao; Aleshcheva, Ganna; Pietsch, Jessica; Bauer, Johann; Grimm, Daniela

The impact of hypergravity and vibration on gene and protein expression of thyroid cells
In: Microgravity science and technology - Heidelberg: Springer, 2007, Bd. 28.2016, 3, S. 261-274

Begutachteter Zeitschriftenartikel

Aleshcheva, Ganna; Bauer, Johann; Hemmersbach, Ruth; Slumstrup, Lasse; Wehland, Markus; Infanger, Manfred; Grimm, Daniela

Scaffold-free tissue formation under real and simulated microgravity conditions
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, 2004, Bd. 119.2016, Suppl.3, Seite 26-33

2015

Begutachteter Zeitschriftenartikel

Kopp, Sascha; Warnke, Elisabeth; Wehland, Markus; Aleshcheva, Ganna; Magnusson, Nils E.; Hemmersbach, Ruth; Corydon, Thomas Juhl; Bauer, Johann; Infanger, Manfred; Grimm, Daniela

Mechanisms of three-dimensional growth of thyroid cells during long-term simulated microgravity
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 5.2015, Art.-Nr. 16691, insges. 17 S.

Begutachteter Zeitschriftenartikel

Svejgaard, Benjamin; Wehland, Markus; Ma, Xiao; Kopp, Sascha; Sahana, Jayashree; Warnke, Elisabeth; Aleshcheva, Ganna; Hemmersbach, Ruth; Hauslage, Jens; Grosse, Jirka; Bauer, Johann; Corydon, Thomas Juhl; Islam, Tawhidul; Infanger, Manfred; Grimm, Daniela

Common effects on cancer cells exerted by a random positioning machine and a 2D clinostat
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 10.2015, 8, Art. e0135157, insges. 22 S.

Begutachteter Zeitschriftenartikel

Nielsen, Ole H.; Grimm, Daniela; Wehland, Markus; Bauer, Johann; Magnusson, Nils E.

Anti-angiogenic drugs in the treatment of metastatic renal cell carcinoma - Advances in clinical application
In: Current vascular pharmacology - Hilversum [u.a.]: Bentham Science Publ., 2003, Bd. 13.2015, 3, S. 381-391

Begutachteter Zeitschriftenartikel

Wehland, Markus; Aleshcheva, Ganna; Schulz, Herbert; Saar, Katrin; Hübner, Norbert; Hemmersbach, Ruth; Braun, Markus; Ma, Xiao; Frett, Timo; Warnke, Elisabeth; Riwaldt, Stefan; Pietsch, Jessica; Corydon, Thomas J.; Infanger, Manfred; Grimm, Daniela

Differential gene expression of human chondrocytes cultured under short-term altered gravity conditions during parabolic flight maneuvers
In: Cell communication and signaling - London: Biomed Central, Bd. 13.2015, Art.-Nr. 18, insges. 13 S.

Begutachteter Zeitschriftenartikel

Aleshcheva, Ganna; Wehland, Markus; Sahana, Jayashree; Bauer, Johann; Corydon, Thomas J.; Hemmersbach, Ruth; Frett, Timo; Egli, Marcel; Infanger, Manfred; Grosse, Jirka; Grimm, Daniela

Moderate alterations of the cytoskeleton in human chondrocytes after short-term microgravity produced by parabolic flight maneuvers could be prevented by up-regulation of BMP-2 and SOX-9
In: The FASEB journal - Bethesda, Md: FASEB, 1987, Bd. 29.2015, 6, S. 2303-2314

Begutachteter Zeitschriftenartikel

Fisker, Filip Y.; Grimm, Daniela; Wehland, Markus

Third-generation beta-adrenoceptor antagonists in the treatment of hypertension and heart failure
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, 2004, Bd. 117.2015, 1, S. 5-14

2014

Begutachteter Zeitschriftenartikel

Grosse, Jirka; Warnke, Elisabeth; Wehland, Markus; Pietsch, Jessica; Pohl, Fabian; Wise, Petra; Magnusson, Nils E.; Eilles, Christoph; Grimm, Daniela

Mechanisms of apoptosis in irradiated and sunitinib-treated follicular thyroid cancer cells
In: Apoptosis - Dordrecht [u.a.]: Springer Science + Business Media B.V, 1996, Bd. 19.2014, 3, S. 480-490

Begutachteter Zeitschriftenartikel

Grimm, Daniela; Pietsch, Jessica; Wehland, Markus; Richter, Peter; Strauch, Sebastian M.; Lebert, Michael; Magnusson, Nils Erik; Wise, Petra; Bauer, Johann

The impact of microgravity-based proteomics research
In: Expert review of proteomics - Abingdon: Taylor & Francis Group, 2004, Bd. 11.2014, 4, S. 465-476

Begutachteter Zeitschriftenartikel

Ulbrich, Claudia; Wehland, Markus; Pietsch, Jessica; Aleshcheva, Ganna; Wise, Petra; Loon, Jack; Magnusson, Nils; Infanger, Manfred; Grosse, Jirka; Eilles, Christoph; Sundaresan, Alamelu; Grimm, Daniela

The impact of simulated and real microgravity on bone cells and mesenchymal stem cells
In: BioMed research international - New York [u.a.]: Hindawi, 2014, Art.-ID 928507, insges. 15 S.

Begutachteter Zeitschriftenartikel

Warnke, Elisabeth; Pietsch, Jessica; Wehland, Markus; Bauer, Johann; Infanger, Manfred; Görög, Mark; Hemmersbach, Ruth; Braun, Markus; Ma, Xiao; Sahana, Jayashree; Grimm, Daniela

Spheroid formation of human thyroid cancer cells under simulated microgravity - a possible role of CTGF and CAV1
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 12.2014, Art.-Nr. 32, insges. 11 S.

2013

Begutachteter Zeitschriftenartikel

Grosse, Jirka; Warnke, Elisabeth; Pohl, Fabian; Magnusson, Nils E.; Wehland, Markus; Infanger, Manfred; Eilles, Christoph; Grimm, Daniela

Impact of sunitinib on human thyroid cancer cells
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 32 (2013), 1, S. 154-170

Begutachteter Zeitschriftenartikel

Ma, Xiao; Wehland, Markus; Aleshcheva, Ganna; Hauslage, Jens; Waßer, Kai; Hemmersbach, Ruth; Infanger, Manfred; Bauer, Johann; Grimm, Daniela

Interleukin-6 expression under gravitational stress due to vibration and hypergravity in follicular thyroid cancer cells
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 8.2013, 7, Art.-Nr. e68140, insges. 12 S.

Begutachteter Zeitschriftenartikel

Grimm, Daniela Gabriele; Bauer, Johann; Hemmersbach, Ruth; Ulbrich, Claudia; Pietsch, Jessica; Wehland, Markus; Infanger, Manfred

Biotechnologische Nutzung der Schwerelosigkeit für medizinische Forschung - Analyse humaner Zellen nach Schwerelosigkeit : analysis of human cells after weightlessness
In: Flugmedizin, Tropenmedizin, Reisemedizin - Stuttgart: Thieme, Bd. 20 (2013), 4, S. 173-178

Begutachteter Zeitschriftenartikel

Pietsch, Jessica; Ma, Xiao; Wehland, Markus; Aleshcheva, Ganna; Schwarzwälder, Achim; Segerer, Jürgen; Birlem, Maria; Horn, Astrid; Bauer, Johann; Infanger, Manfred; Grimm, Daniela

Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission
In: Biomaterials - Amsterdam [u.a.]: Elsevier Science, Bd. 34 (2013), 31, S. 7694-7705

Begutachteter Zeitschriftenartikel

Wehland, Markus; Ma, Xiao; Braun, Markus; Hauslage, Jens; Hemmersbach, Ruth; Bauer, Johann; Grosse, Jirka; Infanger, Manfred; Grimm, Daniela

The impact of altered gravity and vibration on endothelial cells during a parabolic flight
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 31 (2013), 2/3, S. 432-451

Begutachteter Zeitschriftenartikel

Wehland, Markus; Bauer, Johann; Magnusson, Nils E.; Infanger, Manfred; Grimm, Daniela

Biomarkers for anti-angiogenic therapy in cancer
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 14.2013, 5, S. 9338-9364

2012

Originalartikel in begutachteter internationaler Zeitschrift

Grosse, Jirka; Wehland, Markus; Pietsch, Jessica; Ma, Xiao; Ulbrich, Claudia; Schulz, Herbert; Saar, Katrin; Hübner, Norbert; Hauslage, Jens; Hemmersbach, Ruth; Braun, Markus; Loon, Jack; Vagt, Nicole; Infanger, Manfred; Eilles, Christoph; Egli, Marcel; Richter, Peter; Baltz, Theo; Einspanier, Ralf; Sharbati, Soroush; Grimm, Daniela

Short-term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells
In: The FASEB journal/ Federation of American Societies for Experimental Biology - Bethesda, Md.: FASEB, Bd. 26 (2012), 2, S. 639-655

Originalartikel in begutachteter internationaler Zeitschrift

Grosse, Jirka; Wehland, Markus; Pietsch, Jessica; Schulz, Herbert; Saar, Katrin; Hübner, Norbert; Eilles, Christoph; Bauer, Johann; Abou-El-Ardat, Khalil; Baatout, Sarah; Ma, Xiao; Infanger, Manfred; Hemmersbach, Ruth; Grimm, Daniela

Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids
In: The FASEB journal/ Federation of American Societies for Experimental Biology - Bethesda, Md.: FASEB, Bd. 26 (2012), 12, S. 5124-5140

Originalartikel in begutachteter internationaler Zeitschrift

Wehland, Markus; Bauer, Johann; Infanger, Manfred; Grimm, Daniela

Target-based anti-angiogenic therapy in breast cancer
In: Current pharmaceutical design: a timely review journal on recent advances in drug design - Hilversum: Bentham Science Publ., Bd. 18 (2012), 27, S. 4244-4257

Originalartikel in begutachteter internationaler Zeitschrift

Wehland, Markus; Grosse, Jirka; Simonsen, Ulf; Infanger, Manfred; Bauer, Johann; Grimm, Daniela

The effects of newer beta-adrenoceptor antagonists on vascular function in cardiovascular disease
In: Current vascular pharmacology: the journal for current and in-depth reviews on vascular pharmacology - San Francisco, Calif.: Bentham, 2003, Bd. 10.2012, 3, S. 378-390

2011

Originalartikel in begutachteter internationaler Zeitschrift

Ulbrich, Claudia; Pietsch, Jessica; Grosse, Jirka; Wehland, Markus; Schulz, Herbert; Saar, Katrin; Hübner, Norbert; Hauslage, Jens; Hemmersbach, Ruth; Braun, Markus; Loon, Jack van; Vagt, Nicole; Egli, Marcel; Richter, Peter Georg; Einspanier, Ralf; Sharbati, Soroush; Baltz, Theo; Infanger, Manfred; Ma, Xiao; Grimm, Daniela

Differential gene regulation under altered gravity conditions in follicular thyroid cancer cells: relationship between the extracellular matrix and the cytoskeleton
In: Cellular physiology and biochemistry - Basel : Karger, Bd. 28 (2011), Heft 2, S. 185-198

Projekte

Aktuelle Projekte

3D Printing of Ultra-fideLity tissues using Space for anti-ageing solutions on Earth - Acronym - PULSE
Laufzeit: 01.04.2023 bis 31.03.2028

Bioprinting in Space is one of the novel promising and perspective research directions in the rapidly emerging field of biofabrication. There are several advantages of bioprinting in Space. First, under the conditions of microgravity, it is possible to bioprint constructs employing more fluidic channels and, thus, more biocompatible bio-inks. Second, microgravity conditions enable 3D bioprinting of tissue and organ constructs of more complex geometries with voids, cavities, and tunnels. Third, a novel scaffold-free, label-free, and nozzle-free technology based on multi-levitation principles can be implemented under the condition of microgravity. The ideal Space bioprinters must be safe, automated, compact, and user friendly. Thus, there are no doubts that systematic exploration of 3D bioprinting in Space will advance biofabrication and bioprinting technology per se. Vice versa 3D bioprinted tissues could be used to study pathophysiological biological phenomena when exposed to microgravity and cosmic radiation that will be useful on Earth to understand ageing conditioning of tissues, and in space for the crew of deep space manned missions. In PULSE, we aim at developing a radical new bioprinting technology based on multiple levitation principles and to use Space as an accelerator of ageing on Earth. As a proof of concept study, we will use this newly developed bioprinting technology to create cardiac 3D in vitro models able to better mimic cardiac physiology compared to organoids. We will use such models to study cardiac ageing and test the efficacy of antiinflammatory/ anti-oxidative drugs with anti-ageing potential.

Projekt im Forschungsportal ansehen

Künstliche Intelligenz trifft auf die Krebsforschung im Weltraum - als Teil des Verbundvorhaben AIMS (Artificial lntelligence Meets Space) - Acronym - AMCRIS -
Laufzeit: 01.09.2022 bis 31.08.2025

Insgesamt ist unser u¨bergeordnetes Ziel die Ermittlung des Einflusses von µg auf humane
Mammakarzinomzellen mit Fokus auf die Mechanismen des dreidimensionalen Wachstums. Zu dessen Erreichung unterteilt sich das beantragte Forschungsvorhaben in zwei wissenschaftliche und technologische Teilziele:
AMCRIS-AP1: Integration bildanalytischer KI-Verfahren fu¨r die Optimierung der Auswertung von unter s-µg und r-µg aufgenommenen hochauflösenden FLUMIAS Bilddaten. Von der KI-gestu¨tzten Bildanalyse erwarten wir:
1. Identifikation und Tracking von Sphäroiden sowie Identifikation und gesicherte Quantifizierung
intrazellulärer molekularer Strukturen und Organellen
2. Generierung von 3D Sphäroid-Modellen unter Verwendung von FLUMIAS Z-Stack Aufnahmen
3. Eine klare Differenzierung von Präparationsartefakten zu Zell- und Zellcluster-Eigenschaften
AMCRIS-AP2: Projektu¨bergreifende Analyse der unter r- und s-µg gewonnenen RNAseq-Daten unter Einbeziehung von ¨Deep Learning¨ Algorithmen und deren analytische Verknu¨pfung mit generellen und eigenen unter Langzeit-µg ermittelten epigenetischen Daten. Von der KI-gestu¨tzten Datenanalyse erwarten wir:
1. Identifikation von µg-verursachten epigenetischen, transkriptionellen und proteomischen Effekten
2. Differenzierung von µg-verursachten und/oder erkrankungsdiskriminierenden Genklassen
3. Differenzierung von zelltypspezifischen, erkrankungsspezifischen und u¨bergreifenden Effekten.
4. Durch anschließende Interaktionsnetzwerkanalysen erwarten wir eine präzise Abbildung der Signalwege µg-basierter Differenzierung und Veränderung von Tumorzellen.

Durch Kombination der Teilvorhaben AMCRIS-AP1 und AMCRIS-AP2 soll ein physiologisch-biochemisches 3D-Modell der Sphäroid-Bildung als Modell fu¨r die Metastasierung von Tumoren entwickelt werden.

Projekt im Forschungsportal ansehen

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