Dr. rer. nat. Markus Wehland
Dr. rer. nat. Markus Wehland
AG Tissue Engineering & Translationale Regenerative Medizin
2023
Begutachteter Zeitschriftenartikel
A systematic review of the effect of vericiguat on patients with heart failure
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 14, Artikel 11826, insges. 18 S.
Begutachteter Zeitschriftenartikel
Long-term simulation of microgravity induces changes in gene expression in breast cancer cells
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 2, Artikel 1181, insges. 23 S.
Begutachteter Zeitschriftenartikel
Effects of high glucose on human endothelial cells exposed to simulated microgravity
In: Biomolecules - Basel : MDPI, Bd. 13 (2023), Heft 2, Artikel 189, insges. 22 S.
Begutachteter Zeitschriftenartikel
Cabozantinib, vandetanib, pralsetinib and selpercatinib as treatment for progressed medullary thyroid cancer with a main focus on hypertension as adverse effect
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 3, Artikel 2312, insges. 18 S.
Begutachteter Zeitschriftenartikel
Latest knowledge on the role of vitamin D in hypertension
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 24 (2023), Heft 5, Artikel 4679, insges. 22 S.
Begutachteter Zeitschriftenartikel
Current knowledge about the impact of microgravity on gene regulation
In: Cells - Basel : MDPI, Bd. 12 (2023), Heft 7, Artikel 1043, insges. 59 S.
2022
Begutachteter Zeitschriftenartikel
The cardiovascular system in space - focus on in vivo and in vitro studies
In: Biomedicines - Basel : MDPI, Bd. 10 (2022), Heft 1, Artikel 59, insges. 29 S.
Begutachteter Zeitschriftenartikel
Latest knowledge about changes in the proteome in microgravity
In: Expert review of proteomics - Abingdon : Taylor & Francis Group, Bd. 19 (2022), Heft 1, S. 43-59
Begutachteter Zeitschriftenartikel
Three-dimensional growth of prostate cancer cells exposed to simulated microgravity
In: Frontiers in cell and developmental biology - Lausanne : Frontiers Media, Bd. 10 (2022), Artikel 841017, insges. 21 S.
Begutachteter Zeitschriftenartikel
The fight against cancer by microgravity - the multicellular spheroid as a metastasis model
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 23 (2022), Heft 6, Artikel 3073, insges. 45 S.
Begutachteter Zeitschriftenartikel
In prostate cancer cells cytokines are early responders to gravitational changes occurring in parabolic flights
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 14, insges. 18 S.
Begutachteter Zeitschriftenartikel
Microgravity-related changes in bone density and treatment options - a systematic review
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 23 (2022), 15, insges. 23 S.
Begutachteter Zeitschriftenartikel
Current knowledge about the new drug firibastat in arterial hypertension
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 23 (2022), Heft 3, Artikel 1459, insges. 13 S.
2021
Begutachteter Zeitschriftenartikel
The effect of continuous positive airway pressure therapy on obstructive sleep apnea-related hypertension
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 5, insges. 14 S.
Begutachteter Zeitschriftenartikel
Changes in exosomal miRNA composition in thyroid cancer cells after prolonged exposure to real microgravity in space
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 23, insges. 24 S.
Begutachteter Zeitschriftenartikel
Kinase-inhibitors in iodine-refractory differentiated thyroid cancer - focus on occurrence, mechanisms, and management of treatment-related hypertension
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 22, insges. 23 S.
Begutachteter Zeitschriftenartikel
The CellBox-2 Mission to the International Space Station - thyroid cancer cells in space
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 16, insges. 21 S.
Begutachteter Zeitschriftenartikel
Role of apoptosis in wound healing and apoptosis alterations in microgravity
In: Frontiers in Bioengineering and Biotechnology - Lausanne: Frontiers Media, 2013, Bd. 9 (2021), insges. 22 S.
Begutachteter Zeitschriftenartikel
Alterations of growth and focal adhesion molecules in human breast cancer cells exposed to the random positioning machine
In: Frontiers in cell and developmental biology - Lausanne: Frontiers Media, 2013, Bd. 9 (2021), insges. 17 S.
Begutachteter Zeitschriftenartikel
SARS-CoV-2 and hypertension
In: Physiological reports - [S.l.]: Wiley, 2013, Bd. 9 (2021), insges. 14 S.
Begutachteter Zeitschriftenartikel
Changes in exosome release in thyroid cancer cells after prolonged exposure to real microgravity in space
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 22 (2021), 4, insges. 19 S.
2020
Begutachteter Zeitschriftenartikel
Multikinase inhibitor treatment in thyroid cancer
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 1, Art.-Nr. 10, insges. 19 Seiten
Begutachteter Zeitschriftenartikel
The role of SOX family members in solid tumours and metastasis
In: Seminars in cancer biology - London: Academic Press, 1995, Bd. 67 (2020), 1, S. 122-153, 2019
Begutachteter Zeitschriftenartikel
Selective surgical treatment of the intraneural perineurioma of the femoral nerve by tumor resection and graft repair
In: Journal of case reports and medical images - Reno, NV: MedDocs Publishers LLC, 2018, Vol. 3.2020, 1, 1060, 5 Seiten
Begutachteter Zeitschriftenartikel
Tissue engineering of cartilage using a random positioning machine
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International - Vol. 21.2020, 24, 9596, insgesamt 24 Seiten
Begutachteter Zeitschriftenartikel
Breast cancer cells in microgravity - new aspects for cancer research
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 19, Art.-Nr. 7345, insges. 22 Seiten
Begutachteter Zeitschriftenartikel
Science between bioreactors and space research - response to comments by Joseph J. Bevelacqua et al. on Dexamethasone Inhibits Spheroid Formation of Thyroid Cancer Cells Exposed to Simulated Microgravity
In: Cells - Basel: MDPI, 2012, Vol. 9.2020, 8, Art.-Nr. 1763, insges. 3 Seiten
Begutachteter Zeitschriftenartikel
The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells
In: Stem cells translational medicine - Durham: AlphaMed Press, 2012, Bd. 9 (2020), 8, S. 882-894
Begutachteter Zeitschriftenartikel
Insight in adhesion protein sialylation and microgravity dependent cell adhesion - an omics network approach
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 5, Art.-Nr. 1749, insges. 23 Seiten
Begutachteter Zeitschriftenartikel
Endothelin receptor antagonists - status quo and future perspectives for targeted therapy
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd. 9.2020, 3, Art.-Nr. 824, insges. 29 Seiten
Begutachteter Zeitschriftenartikel
An evaluation of the fixed-dose combination sacubitril/valsartan for the treatment of arterial hypertension
In: Expert opinion on pharmacotherapy - Abingdon, Oxon: Routledge, Taylor & Francis, Bd. 21 (2020), 10, S. 1133-1143
Begutachteter Zeitschriftenartikel
Simulated microgravity influences VEGF, MAPK, and PAM signaling in prostate cancer cells
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 4, Art.-Nr. 1263, insges. 26 Seiten
Begutachteter Zeitschriftenartikel
Dexamethasone inhibits spheroid formation of thyroid cancer cells exposed to simulated microgravity
In: Cells - Basel: MDPI, 2012, Vol. 9.2020, 2, Art.-Nr. 367, insges. 25 Seiten
Begutachteter Zeitschriftenartikel
The vasoactive mas receptor in essential hypertension
In: Journal of Clinical Medicine - Basel: MDPI, 2012, Bd. 9.2020, 1, Art.-Nr. 267, insges. 12 Seiten
Begutachteter Zeitschriftenartikel
Potential beneficial effects of vitamin D in coronary artery disease
In: Nutrients - Basel: MDPI, 2009, Vol.12.2020, 1, Art.-Nr. 99, insges. 22 Seiten
Begutachteter Zeitschriftenartikel
Alteration of cytoskeleton morphology and gene expression in human breast cancer cells under simulated microgravity
In: Cell journal (Yakhteh) - [S.l.]: Inst., 2011, Bd. 22 (2020), 1, S. 106-114
Begutachteter Zeitschriftenartikel
The prostacyclin analogue treprostinil in the treatment of pulmonary arterial hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 126 (2020), 1, S. 32-42
2019
Abstract
Alterations of the cytoskeleton in breast cancer cells during microgravity visualised by FLUMIAS live-cell imaging
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, 2007, Bd. 10.2019, Abstract 8, insges. 3 S.
Abstract
Growing tissues in space
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, 2007, Bd. 10.2019, Abstract 14, insges. 3 S.
Abstract
Microgravity-based modulation of VEGF expression in human thyroid carcinoma cells
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, 2007, Bd. 10.2019, Abstract 2, insges. 4 S.
Begutachteter Zeitschriftenartikel
Morphological and molecular changes in juvenile normal human fibroblasts exposed to simulated microgravity
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 9.2019, Art.-Nr. 11882, insges. 22 S.
Begutachteter Zeitschriftenartikel
Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 13, Art.-Nr. 3156, insges. 25 S.
Begutachteter Zeitschriftenartikel
A focus on riociguat in the treatment of pulmonary arterial hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 125 (2019), 3, S. 202-214
Begutachteter Zeitschriftenartikel
Fighting thyroid cancer with microgravity research
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 10, Art.-Nr. 2553, insges. 21 S.
Begutachteter Zeitschriftenartikel
Nebivolol in the treatment of arterial hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 125 (2019), 3, S. 189-201
Begutachteter Zeitschriftenartikel
Growth of endothelial cells in space and in simulated microgravity - a comparison on the secretory level
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 52 (2019), 5, S. 1039-1060
Begutachteter Zeitschriftenartikel
Growing blood vessels in space - preparation studies of the SPHEROIDS project using related ground-based studies
In: Acta astronautica - Amsterdam [u.a.]: Elsevier Science, Bd. 159 (2019), S. 267-272
Begutachteter Zeitschriftenartikel
Changes in human foetal osteoblasts exposed to the random positioning machine and bone construct tissue engineering
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 6, Art.-Nr. 1357, insges. 26 S.
Begutachteter Zeitschriftenartikel
Tyrosine kinase inhibitor-induced hypertension - role of hypertension as a biomarker in cancer treatment
In: Current vascular pharmacology - Hilversum [u.a.]: Bentham Science Publ., Bd. 17 (2019), 6, S. 618-634
Begutachteter Zeitschriftenartikel
The effects of oral L-arginine and L-citrulline supplementation on blood pressure
In: Nutrients - Basel: MDPI, 2009, Bd. 11.2019, 7, Art.-Nr. 1679, insges. 14 S.
Begutachteter Zeitschriftenartikel
Beneficial effects of low frequency vibration on human chondrocytes in vitro
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 53 (2019), Heft 4, S. 623-637
Begutachteter Zeitschriftenartikel
Short-term microgravity influences cell adhesion in human breast cancer cells
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 22, Art.-Nr. 5730, insges. 27 Seiten
Begutachteter Zeitschriftenartikel
Bioactive candy - effects of licorice on the cardiovascular system
In: Foods - Basel: MDPI, 2012, Bd.8.2019, 10, Art.-Nr. 495, insges. 20 Seiten
Begutachteter Zeitschriftenartikel
Drug-induced hypertension caused by multikinase inhibitors (sorafenib, sunitinib, lenvatinib and axitinib) in renal cell carcinoma treatment
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd.20.2019, 19, Art.-Nr. 4712, insges. 23 Seiten
2018
Begutachteter Zeitschriftenartikel
Microgravity affects thyroid cancer cells during the TEXUS-53 mission stronger than hypergravity
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 12, Art.-Nr. 4001, insges. 20 S.
Begutachteter Zeitschriftenartikel
The combination of valsartan and sacubitril in the treatment of hypertension and heart failure - an update
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 122 (2018), 1, S. 9-18
Begutachteter Zeitschriftenartikel
The impact of vitamin D in the treatment of essential hypertension
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 2, Art.-Nr. 455, insges. 14 S.
Begutachteter Zeitschriftenartikel
The role of NF[kappa]B in spheroid formation of human breast cancer cells cultured on the Random Positioning Machine
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 8.2018, Art.-Nr. 921, insges. 17 S.
Begutachteter Zeitschriftenartikel
Thyroid cancer cells in space during the TEXUS-53 sounding rocket mission - the THYROID project
In: Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature - Bd. 8.2018, Art.-Nr. 10355, insges. 13 S.
Begutachteter Zeitschriftenartikel
Decreased E-cadherin in MCF7 human breast cancer cells forming multicellular spheroids exposed to simulated microgravity
In: Proteomics - Weinheim: Wiley VCH, Bd. 18.2018, 13, Art.-Nr. e1800015
Begutachteter Zeitschriftenartikel
Pathway analysis hints towards beneficial effects of long-term vibration on human chondrocytes
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 47 (2018), 4, S. 1729-1741
Begutachteter Zeitschriftenartikel
Semantic analysis of posttranslational modification of proteins accumulated in thyroid cancer cells exposed to simulated microgravity
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 8, Art.-Nr. 2257, insges. 16 S.
Begutachteter Zeitschriftenartikel
A focus on macitentan in the treatment of pulmonary arterial hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, Bd. 123 (2018), 2, S. 103-113
Begutachteter Zeitschriftenartikel
Pazopanib, cabozantinib, and vandetanib in the treatment of progressive medullary thyroid cancer with a special focus on the adverse effects on hypertension
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 10, Art.-Nr. 3258, insges. 15 S.
Begutachteter Zeitschriftenartikel
Tissue engineering under microgravity conditions - use of stem cells and specialized cells
In: Stem Cells and Development - Larchmont, NY: Liebert, Bd. 27 (2018), 12, S. 787-804
Begutachteter Zeitschriftenartikel
Vascular endothelial growth factor enhances proliferation of human tenocytes and promotes tenogenic gene expression
In: Plastic and reconstructive surgery - Philadelphia, Pa.: Lippincott Williams & Wilkins, Bd. 142 (2018), 5, S. 1240-1247
2017
Abstract
Scaffold-freies 3D-Zellkulturmodell humaner Lungenkarzinomzellen unter simulierter Mikrogravitation
In: Zentralblatt für Chirurgie - Stuttgart [u.a.]: Thieme, 2000, Bd. 142.2017, S01, insges. 1 S.
Buchbeitrag
Tissue engineering in microgravity
In: Biotechnology in Space - Cham: Springer, 2017 . - 2017, S. 73-85
Begutachteter Zeitschriftenartikel
Hypertension caused by lenvatinib and everolimus in the treatment of metastatic renal cell carcinoma
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 8, Art.-Nr. 1736, insges. 12 S.
Begutachteter Zeitschriftenartikel
Cytokine release and focal adhesion proteins in normal thyroid cells cultured on the random positioning machine
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 43.2017, 1, S. 257-270
Begutachteter Zeitschriftenartikel
Proteome analysis of human follicular thyroid cancer cells exposed to the random positioning machine
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 3, Art.-Nr. 546, insges. 13 S.
Begutachteter Zeitschriftenartikel
A special focus on selexipag - treatment of pulmonary arterial hypertension
In: Current pharmaceutical design: dispatches from the front line of drug design - Hilversum: Bentham Science Publ., 2000, Bd. 23.2017, 34, S. 5191-5199
Begutachteter Zeitschriftenartikel
Preparation of A spaceflight - apoptosis search in sutured wound healing models
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 12, Art.-Nr. 2604, insges. 22 S.
Begutachteter Zeitschriftenartikel
Azilsartan medoxomil, an angiotensin II receptor antagonist for the treatment of hypertension
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, 2004, Bd. 121.2017, 4, S. 225-233
Begutachteter Zeitschriftenartikel
The adverse effect of hypertension in the treatment of thyroid cancer with multi-kinase inhibitors
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 3, Art.-Nr. 625, insges. 19 S.
2016
Begutachteter Zeitschriftenartikel
LCZ696 (valsartan/sacubitril) - a possible new treatment for hypertension and heart failure
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, 2004, Bd. 118.2016, 1, S. 14-22
Begutachteter Zeitschriftenartikel
Tissue engineering of cartilage on ground-based facilities
In: Microgravity science and technology: international journal for microgravity research and applications - Heidelberg: Springer, 2007, Bd. 28.2016, 3, S. 237-245
Begutachteter Zeitschriftenartikel
Annotated gene and proteome data support recognition of interconnections between the results of different experiments in space research
In: Microgravity science and technology - Heidelberg: Springer, 2007, Bd. 28.2016, 3, S. 357-365
Begutachteter Zeitschriftenartikel
Alterations of the cytoskeleton in human cells in space proved by life-cell imaging
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 6.2016, Art.-Nr. 20043, insges. 14 S.
Begutachteter Zeitschriftenartikel
Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 6.2016, Art.-Nr. 26887, insges. 18 S.
Begutachteter Zeitschriftenartikel
Pathways regulating spheroid formation of human follicular thyroid cancer cells under simulated microgravity conditions - A genetic approach
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 17 (2016), 4, Art.-Nr. 528, insges. 20 S.
Begutachteter Zeitschriftenartikel
Effects and role of multikinase inhibitors in thyroid cancer
In: Current pharmaceutical design - Hilversum: Bentham Science Publ, 2000, Bd. 22.2016, 39, S. 5915-5926
Begutachteter Zeitschriftenartikel
The impact of microgravity on bone in humans
In: Bone: cell molecular biology, pathophysiology, treatment ; official journal of the International Bone and Mineral Society - Amsterdam [u.a.]: Elsevier Science, 1985, Bd. 87.2016, S. 44-56
Begutachteter Zeitschriftenartikel
Latest results for anti-angiogenic drugs in cancer treatment
In: Current pharmaceutical design - Hilversum: Bentham Science Publ, 2000, Bd. 22.2016, 39, S. 5927-5942
Begutachteter Zeitschriftenartikel
Genetic low nephron number hypertension is associated with altered expression of key components of the renin-angiotensin system during nephrogenesis
In: Journal of perinatal medicine - Berlin [u.a.]: de Gruyter, 1973, Bd. 44.2016, 6, S. 705-709
Begutachteter Zeitschriftenartikel
Thyroid cells exposed to simulated microgravity conditions - comparison of the fast rotating clinostat and the random positioning machine
In: Microgravity science and technology - Heidelberg: Springer, 2007, Bd. 28.2016, 3, S. 247-260
Begutachteter Zeitschriftenartikel
The impact of hypergravity and vibration on gene and protein expression of thyroid cells
In: Microgravity science and technology - Heidelberg: Springer, 2007, Bd. 28.2016, 3, S. 261-274
Begutachteter Zeitschriftenartikel
Scaffold-free tissue formation under real and simulated microgravity conditions
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, 2004, Bd. 119.2016, Suppl.3, Seite 26-33
2015
Begutachteter Zeitschriftenartikel
Mechanisms of three-dimensional growth of thyroid cells during long-term simulated microgravity
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 5.2015, Art.-Nr. 16691, insges. 17 S.
Begutachteter Zeitschriftenartikel
Common effects on cancer cells exerted by a random positioning machine and a 2D clinostat
In: PLOS ONE - San Francisco, California, US: PLOS, 2006, Bd. 10.2015, 8, Art. e0135157, insges. 22 S.
Begutachteter Zeitschriftenartikel
Anti-angiogenic drugs in the treatment of metastatic renal cell carcinoma - Advances in clinical application
In: Current vascular pharmacology - Hilversum [u.a.]: Bentham Science Publ., 2003, Bd. 13.2015, 3, S. 381-391
Begutachteter Zeitschriftenartikel
Differential gene expression of human chondrocytes cultured under short-term altered gravity conditions during parabolic flight maneuvers
In: Cell communication and signaling - London: Biomed Central, Bd. 13.2015, Art.-Nr. 18, insges. 13 S.
Begutachteter Zeitschriftenartikel
Moderate alterations of the cytoskeleton in human chondrocytes after short-term microgravity produced by parabolic flight maneuvers could be prevented by up-regulation of BMP-2 and SOX-9
In: The FASEB journal - Bethesda, Md: FASEB, 1987, Bd. 29.2015, 6, S. 2303-2314
Begutachteter Zeitschriftenartikel
Third-generation beta-adrenoceptor antagonists in the treatment of hypertension and heart failure
In: Basic & clinical pharmacology & toxicology - Oxford: Wiley-Blackwell, 2004, Bd. 117.2015, 1, S. 5-14
2014
Begutachteter Zeitschriftenartikel
Mechanisms of apoptosis in irradiated and sunitinib-treated follicular thyroid cancer cells
In: Apoptosis - Dordrecht [u.a.]: Springer Science + Business Media B.V, 1996, Bd. 19.2014, 3, S. 480-490
Begutachteter Zeitschriftenartikel
The impact of microgravity-based proteomics research
In: Expert review of proteomics - Abingdon: Taylor & Francis Group, 2004, Bd. 11.2014, 4, S. 465-476
Begutachteter Zeitschriftenartikel
The impact of simulated and real microgravity on bone cells and mesenchymal stem cells
In: BioMed research international - New York [u.a.]: Hindawi, 2014, Art.-ID 928507, insges. 15 S.
Begutachteter Zeitschriftenartikel
Spheroid formation of human thyroid cancer cells under simulated microgravity - a possible role of CTGF and CAV1
In: Cell communication and signaling - London: Biomed Central, 2003, Bd. 12.2014, Art.-Nr. 32, insges. 11 S.
2013
Begutachteter Zeitschriftenartikel
Impact of sunitinib on human thyroid cancer cells
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 32 (2013), 1, S. 154-170
Begutachteter Zeitschriftenartikel
Interleukin-6 expression under gravitational stress due to vibration and hypergravity in follicular thyroid cancer cells
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 8.2013, 7, Art.-Nr. e68140, insges. 12 S.
Begutachteter Zeitschriftenartikel
Biotechnologische Nutzung der Schwerelosigkeit für medizinische Forschung - Analyse humaner Zellen nach Schwerelosigkeit : analysis of human cells after weightlessness
In: Flugmedizin, Tropenmedizin, Reisemedizin - Stuttgart: Thieme, Bd. 20 (2013), 4, S. 173-178
Begutachteter Zeitschriftenartikel
Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission
In: Biomaterials - Amsterdam [u.a.]: Elsevier Science, Bd. 34 (2013), 31, S. 7694-7705
Begutachteter Zeitschriftenartikel
The impact of altered gravity and vibration on endothelial cells during a parabolic flight
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, Bd. 31 (2013), 2/3, S. 432-451
Begutachteter Zeitschriftenartikel
Biomarkers for anti-angiogenic therapy in cancer
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 14.2013, 5, S. 9338-9364
2012
Originalartikel in begutachteter internationaler Zeitschrift
Short-term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells
In: The FASEB journal/ Federation of American Societies for Experimental Biology - Bethesda, Md.: FASEB, Bd. 26 (2012), 2, S. 639-655
Originalartikel in begutachteter internationaler Zeitschrift
Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids
In: The FASEB journal/ Federation of American Societies for Experimental Biology - Bethesda, Md.: FASEB, Bd. 26 (2012), 12, S. 5124-5140
Originalartikel in begutachteter internationaler Zeitschrift
Target-based anti-angiogenic therapy in breast cancer
In: Current pharmaceutical design: a timely review journal on recent advances in drug design - Hilversum: Bentham Science Publ., Bd. 18 (2012), 27, S. 4244-4257
Originalartikel in begutachteter internationaler Zeitschrift
The effects of newer beta-adrenoceptor antagonists on vascular function in cardiovascular disease
In: Current vascular pharmacology: the journal for current and in-depth reviews on vascular pharmacology - San Francisco, Calif.: Bentham, 2003, Bd. 10.2012, 3, S. 378-390
2011
Originalartikel in begutachteter internationaler Zeitschrift
Differential gene regulation under altered gravity conditions in follicular thyroid cancer cells: relationship between the extracellular matrix and the cytoskeleton
In: Cellular physiology and biochemistry - Basel : Karger, Bd. 28 (2011), Heft 2, S. 185-198
Aktuelle Projekte
3D Printing of Ultra-fideLity tissues using Space for anti-ageing solutions on Earth - Acronym - PULSE
Laufzeit: 01.04.2023 bis 31.03.2028
Bioprinting in Space is one of the novel promising and perspective research directions in the rapidly emerging field of biofabrication. There are several advantages of bioprinting in Space. First, under the conditions of microgravity, it is possible to bioprint constructs employing more fluidic channels and, thus, more biocompatible bio-inks. Second, microgravity conditions enable 3D bioprinting of tissue and organ constructs of more complex geometries with voids, cavities, and tunnels. Third, a novel scaffold-free, label-free, and nozzle-free technology based on multi-levitation principles can be implemented under the condition of microgravity. The ideal Space bioprinters must be safe, automated, compact, and user friendly. Thus, there are no doubts that systematic exploration of 3D bioprinting in Space will advance biofabrication and bioprinting technology per se. Vice versa 3D bioprinted tissues could be used to study pathophysiological biological phenomena when exposed to microgravity and cosmic radiation that will be useful on Earth to understand ageing conditioning of tissues, and in space for the crew of deep space manned missions. In PULSE, we aim at developing a radical new bioprinting technology based on multiple levitation principles and to use Space as an accelerator of ageing on Earth. As a proof of concept study, we will use this newly developed bioprinting technology to create cardiac 3D in vitro models able to better mimic cardiac physiology compared to organoids. We will use such models to study cardiac ageing and test the efficacy of antiinflammatory/ anti-oxidative drugs with anti-ageing potential.
Künstliche Intelligenz trifft auf die Krebsforschung im Weltraum - als Teil des Verbundvorhaben AIMS (Artificial lntelligence Meets Space) - Acronym - AMCRIS -
Laufzeit: 01.09.2022 bis 31.08.2025
Insgesamt ist unser u¨bergeordnetes Ziel die Ermittlung des Einflusses von µg auf humane
Mammakarzinomzellen mit Fokus auf die Mechanismen des dreidimensionalen Wachstums. Zu dessen Erreichung unterteilt sich das beantragte Forschungsvorhaben in zwei wissenschaftliche und technologische Teilziele:
AMCRIS-AP1: Integration bildanalytischer KI-Verfahren fu¨r die Optimierung der Auswertung von unter s-µg und r-µg aufgenommenen hochauflösenden FLUMIAS Bilddaten. Von der KI-gestu¨tzten Bildanalyse erwarten wir:
1. Identifikation und Tracking von Sphäroiden sowie Identifikation und gesicherte Quantifizierung
intrazellulärer molekularer Strukturen und Organellen
2. Generierung von 3D Sphäroid-Modellen unter Verwendung von FLUMIAS Z-Stack Aufnahmen
3. Eine klare Differenzierung von Präparationsartefakten zu Zell- und Zellcluster-Eigenschaften
AMCRIS-AP2: Projektu¨bergreifende Analyse der unter r- und s-µg gewonnenen RNAseq-Daten unter Einbeziehung von ¨Deep Learning¨ Algorithmen und deren analytische Verknu¨pfung mit generellen und eigenen unter Langzeit-µg ermittelten epigenetischen Daten. Von der KI-gestu¨tzten Datenanalyse erwarten wir:
1. Identifikation von µg-verursachten epigenetischen, transkriptionellen und proteomischen Effekten
2. Differenzierung von µg-verursachten und/oder erkrankungsdiskriminierenden Genklassen
3. Differenzierung von zelltypspezifischen, erkrankungsspezifischen und u¨bergreifenden Effekten.
4. Durch anschließende Interaktionsnetzwerkanalysen erwarten wir eine präzise Abbildung der Signalwege µg-basierter Differenzierung und Veränderung von Tumorzellen.
Durch Kombination der Teilvorhaben AMCRIS-AP1 und AMCRIS-AP2 soll ein physiologisch-biochemisches 3D-Modell der Sphäroid-Bildung als Modell fu¨r die Metastasierung von Tumoren entwickelt werden.
- Keine Daten im Forschungsportal hinterlegt.
- Forschung in Mikrogravitation: Grundlagen, Methoden, Experimente ( Link zur LV im LSF )