FORSCHUNGSABTEILUNG MIKROGRAVITATION UND TRANSLATIONALE REGENERATIVE MEDIZIN

Dr. rer. medic. Sascha Kopp

Arbeitsgruppenleiter

Dr. rer. medic. Sascha Kopp

Abteilung Mikrogravitation und Translationale Regenerative Medizin
AG Bioreaktoren & Angewandte Mikrogravitationsforschung
Universitätsplatz 2, 39106 Magdeburg, G28-110
Publikationen

2021

Begutachteter Zeitschriftenartikel

Ravichandran, Briyanth;  Grimm, Daniela Gabriele;  Krüger, Marcus;  Kopp, Sascha;  Infanger, Manfred;  Wehland, Markus 

SARS- CoV- 2 and hypertension
In: Physiological reports - [S.l.]: Wiley, 2013, Vol.9.2021, e14800, insgesamt 14 Seiten

2020

Begutachteter Zeitschriftenartikel

Grimm, Daniela Gabriele;  Wehland, Markus;  Corydon, Thomas J.;  Richter, Peter;  Prasad, Binod;  Bauer, Johann;  Egli, Marcel;  Kopp, Sascha;  Lebert, Michael;  Krüger, Marcus 

The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells
In: Stem cells translational medicine: SCTM - Durham: AlphaMed Press, 2012, Bd. 9.2020, 8, S. 882-894

Hybel, Trine Engelbrecht;  Dietrichs, Dorothea;  Sahana, Jayashree;  Corydon, Thomas J.;  Nassef, Mohamed Zakaria;  Wehland, Markus;  Krüger, Marcus;  Magnusson, Nils E.;  Bauer, Johann;  Utpatel, Kirsten;  Infanger, Manfred;  Grimm, Daniela Gabriele;  Kopp, Sascha 

Simulated microgravity influences VEGF, MAPK, and PAM signaling in prostate cancer cells
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 4, Art.-Nr. 1263, insges. 26 Seiten

Krüger, Marcus;  Kopp, Sascha;  Wehland, Markus;  Corydon, Thomas J.;  Grimm, Daniela Gabriele 

Science between bioreactors and space research - response to comments by Joseph J. Bevelacqua et al. on Dexamethasone Inhibits Spheroid Formation of Thyroid Cancer Cells Exposed to Simulated Microgravity
In: Cells: open access journal - Basel: MDPI, 2012, Vol. 9.2020, 8, Art.-Nr. 1763, insges. 3 Seiten

Melnik, Daniela;  Sahana, Jayashree;  Corydon, Thomas J.;  Kopp, Sascha;  Nassef, Mohamed Zakaria;  Wehland, Markus;  Infanger, Manfred;  Grimm, Daniela Gabriele;  Krüger, Marcus 

Dexamethasone inhibits spheroid formation of thyroid cancer cells exposed to simulated microgravity
In: Cells: open access journal - Basel: MDPI, 2012, Vol. 9.2020, 2, Art.-Nr. 367, insges. 25 Seiten

Nassef, Mohamed Zakaria;  Melnik, Daniela;  Kopp, Sascha;  Sahana, Jayashree;  Infanger, Manfred;  Lützenberg, Ronald;  Relja, Borna;  Wehland, Markus;  Grimm, Daniela Gabriele;  Krüger, Marcus 

Breast cancer cells in microgravity - new aspects for cancer research
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 19, Art.-Nr. 7345, insges. 22 Seiten

Wehland, Markus;  Steinwerth, Paul;  Aleshcheva, Ganna;  Sahana, Jayashree;  Hemmersbach, Ruth;  Lützenberg, Ronald;  Kopp, Sascha;  Infanger, Manfred;  Grimm, Daniela Gabriele 

Tissue engineering of cartilage using a random positioning machine
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Vol. 21.2020, 24, 9596, insgesamt 24 Seiten

2019

Abstrakt

Kopp, Sascha;  Krüger, Marcus;  Wehland, Markus;  Bauer, Johann;  Dittrich, Anita;  Infanger, Manfred;  Grimm, Daniela 

Growing tissues in space
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, 2007, Bd. 10.2019, Abstract 14, insges. 3 S.

Melnik, Daniela;  Krüger, Marcus;  Kopp, Sascha;  Wehland, Markus;  Bauer, Johann;  Infanger, Manfred;  Grimm, Daniela 

Microgravity-based modulation of VEGF expression in human thyroid carcinoma cells
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, 2007, Bd. 10.2019, Abstract 2, insges. 4 S.

Nassef, Mohamed Z.;  Kopp, Sascha;  Melnik, Daniela;  Krüger, Marcus;  Wehland, Markus;  Corydon, Thomas J.;  Bauer, Johann;  Infanger, Manfred;  Grimm, Daniela 

Alterations of the cytoskeleton in breast cancer cells during microgravity visualised by FLUMIAS live-cell imaging
In: Frontiers in physiology - Lausanne: Frontiers Research Foundation, 2007, Bd. 10.2019, Abstract 8, insges. 3 S.

Begutachteter Zeitschriftenartikel

Krüger, Marcus;  Melnik, Daniela;  Kopp, Sascha;  Buken, Christoph;  Sahana, Jayashree;  Bauer, Johann;  Wehland, Markus;  Hemmersbach, Ruth;  Corydon, Thomas J.;  Infanger, Manfred;  Grimm, Daniela 

Fighting thyroid cancer with microgravity research
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 10, Art.-Nr. 2553, insges. 21 S.

Krüger, Marcus;  Kopp, Sascha;  Wehland, Markus;  Bauer, Johann;  Baatout, Sarah;  Moreels, Marjan;  Egli, Marcel;  Corydon, Thomas J.;  Infanger, Manfred;  Grimm, Daniela 

Growing blood vessels in space - preparation studies of the SPHEROIDS project using related ground-based studies
In: Acta astronautica: journal of the International Academy of Astronautics - Amsterdam [u.a.]: Elsevier Science, Bd. 159 (2019), S. 267-272

Krüger, Marcus;  Pietsch, Jessica;  Bauer, Johann;  Kopp, Sascha;  Carvalho, Daniel T. O.;  Baatout, Sarah;  Moreels, Marjan;  Melnik, Daniela;  Wehland, Markus;  Egli, Marcel;  Sahana, Jayashree;  Kobberø, Sara Dam;  Corydon, Thomas J.;  Nebuloni, Stefano;  Gass, Samuel;  Evert, Matthias;  Infanger, Manfred;  Grimm, Daniela 

Growth of endothelial cells in space and in simulated microgravity - a comparison on the secretory level
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 52 (2019), 5, S. 1039-1060

Lützenberg, Ronald;  Wehland, Markus;  Solano, Kendrick;  Nassef, Mohamed Z.;  Buken, Christoph;  Melnik, Daniela;  Bauer, Johann;  Kopp, Sascha;  Krüger, Marcus;  Riwaldt, Stefan;  Hemmersbach, Ruth;  Schulz, Herbert;  Infanger, Manfred;  Grimm, Daniela 

Beneficial effects of low frequency vibration on human chondrocytes in vitro
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 53 (2019), 4, S. 623-637

Mann, Vivek;  Grimm, Daniela;  Corydon, Thomas J.;  Krüger, Marcus;  Wehland, Markus;  Riwaldt, Stefan;  Sahana, Jayashree;  Kopp, Sascha;  Bauer, Johann;  Reseland, Janne E.;  Infanger, Manfred;  Lian, Aina Mari;  Okoro, Elvis;  Sundaresan, Alamelu 

Changes in human foetal osteoblasts exposed to the random positioning machine and bone construct tissue engineering
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 6, Art.-Nr. 1357, insges. 26 S.

Nassef, Mohamed Zakaria;  Kopp, Sascha;  Wehland, Markus;  Melnik, Daniela;  Sahana, Jayashree;  Krüger, Marcus;  Corydon, Thomas J.;  Oltmann, Hergen;  Schmitz, Burkhard;  Schütte, Andreas;  Bauer, Thomas J.;  Infanger, Manfred;  Grimm, Daniela 

Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 13, Art.-Nr. 3156, insges. 25 S.

Nassef, Mohamed Zakaria;  Kopp, Sascha;  Melnik, Daniela;  Corydon, Thomas J.;  Sahana, Jayashree;  Krüger, Marcus;  Wehland, Markus;  Bauer, Thomas J.;  Liemersdorf, Christian;  Hemmersbach, Ruth;  Infanger, Manfred;  Grimm, Daniela 

Short-term microgravity influences cell adhesion in human breast cancer cells
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 20.2019, 22, Art.-Nr. 5730, insges. 27 Seiten

2018

Begutachteter Zeitschriftenartikel

Grimm, Daniela;  Egli, Marcel;  Krüger, Marcus;  Riwaldt, Stefan;  Corydon, Thomas J.;  Kopp, Sascha;  Wehland, Markus;  Wise, Petra;  Infanger, Manfred;  Mann, Vivek;  Sundaresan, Alamelu 

Tissue engineering under microgravity conditions - use of stem cells and specialized cells
In: Stem Cells and Development - Larchmont, NY: Liebert, Bd. 27 (2018), 12, S. 787-804

Kopp, Sascha;  Krüger, Marcus;  Bauer, Johann;  Wehland, Markus;  Corydon, Thomas J.;  Sahana, Jayashree;  Nassef, Mohamed Zakaria;  Melnik, Daniela;  Bauer, Thomas J.;  Schulz, Herbert;  Schütte, Andreas;  Schmitz, Burkhard;  Oltmann, Hergen;  Feldmann, Stefan;  Infanger, Manfred;  Grimm, Daniela 

Microgravity affects thyroid cancer cells during the TEXUS-53 mission stronger than hypergravity
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 12, Art.-Nr. 4001, insges. 20 S.

Kopp, Sascha;  Sahana, Jayashree;  Islam, Tawhidul;  Petersen, Asbjørn Graver;  Bauer, Johann;  Corydon, Thomas J.;  Schulz, Herbert;  Saar, Kathrin;  Hübner, Norbert;  Slumstrup, Lasse;  Riwaldt, Stefan;  Wehland, Markus;  Infanger, Manfred;  Luetzenberg, Ronald;  Grimm, Daniela 

The role of NF[kappa]B in spheroid formation of human breast cancer cells cultured on the Random Positioning Machine
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 8.2018, Art.-Nr. 921, insges. 17 S.

Kopp, Sascha;  Krüger, Marcus;  Feldmann, Stefan;  Oltmann, Hergen;  Schütte, Andreas;  Schmitz, Burkhard;  Bauer, Johann;  Schulz, Herbert;  Saar, Kathrin;  Hübner, Norbert;  Wehland, Markus;  Nassef, Mohamed Zakaria;  Melnik, Daniela;  Meltendorf, Stefan;  Infanger, Manfred;  Grimm, Daniela 

Thyroid cancer cells in space during the TEXUS-53 sounding rocket mission - the THYROID project
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 8.2018, Art.-Nr. 10355, insges. 13 S.

Lützenberg, Ronald;  Solano, Kendrick;  Buken, Christoph;  Sahana, Jayashree;  Riwaldt, Stefan;  Kopp, Sascha;  Krüger, Marcus;  Schulz, Herbert;  Saar, Kathrin;  Hübner, Norbert;  Hemmersbach, Ruth;  Bauer, Johann;  Infanger, Manfred;  Grimm, Daniela;  Wehland, Markus 

Pathway analysis hints towards beneficial effects of long-term vibration on human chondrocytes
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 47 (2018), 4, S. 1729-1741

Milling, Rikke Vilsbøll;  Grimm, Daniela;  Krüger, Marcus;  Grosse, Jirka;  Kopp, Sascha;  Bauer, Johann;  Infanger, Manfred;  Wehland, Markus 

Pazopanib, cabozantinib, and vandetanib in the treatment of progressive medullary thyroid cancer with a special focus on the adverse effects on hypertension
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 19.2018, 10, Art.-Nr. 3258, insges. 15 S.

Sahana, Jayashree;  Nassef, Mohamed Zakaria;  Wehland, Markus;  Kopp, Sascha;  Krüger, Marcus;  Corydon, Thomas J.;  Infanger, Manfred;  Bauer, Johann;  Grimm, Daniela 

Decreased E-cadherin in MCF7 human breast cancer cells forming multicellular spheroids exposed to simulated microgravity
In: Proteomics - Weinheim: Wiley VCH, Bd. 18.2018, 13, Art.-Nr. e1800015

Dissertation

Kopp, Sascha;  Stannarius, Ralf [GutachterIn];  Anken, Ralf [GutachterIn] 

The effects of real and simulated microgravity on human cancer cells - [kumulative Dissertation]
In: Magdeburg: Otto-von-Guericke-Universität Magdeburg, 2018, verschiedene Seitenzählung, Illustrationen, Diagramme

2017

Begutachteter Zeitschriftenartikel

Bauer, Johann;  Kopp, Sascha;  Schlagberger, Elisabeth Maria;  Grosse, Jirka;  Sahana, Jayashree;  Riwaldt, Stefan;  Wehland, Markus;  Luetzenberg, Ronald;  Infanger, Manfred;  Grimm, Daniela 

Proteome analysis of human follicular thyroid cancer cells exposed to the random positioning machine
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 3, Art.-Nr. 546, insges. 13 S.

Riwaldt, Stefan;  Monici, Monica;  Petersen, Asbjørn Graver;  Jensen, Uffe Birk;  Evert, Katja;  Pantalone, Desiré;  Utpatel, Kirsten;  Evert, Matthias;  Wehland, Markus;  Krüger, Marcus;  Kopp, Sascha;  Frandsen, Sofie;  Corydon, Thomas;  Sahana, Jayashree;  Bauer, Johann;  Lützenberg, Ronald;  Infanger, Manfred;  Grimm, Daniela 

Preparation of A spaceflight - apoptosis search in sutured wound healing models
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 18.2017, 12, Art.-Nr. 2604, insges. 22 S.

Warnke, Elisabeth;  Pietsch, Jessica;  Kopp, Sascha;  Bauer, Johann;  Sahana, Jayashree;  Wehland, Markus;  Krüger, Marcus;  Hemmersbach, Ruth;  Infanger, Manfred;  Lützenberg, Ronald;  Grimm, Daniela 

Cytokine release and focal adhesion proteins in normal thyroid cells cultured on the random positioning machine
In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 43.2017, 1, S. 257-270

2016

Begutachteter Zeitschriftenartikel

Corydon, Thomas J.;  Kopp, Sascha;  Wehland, Markus;  Braun, Markus;  Schütte, Andreas;  Mayer, Tobias;  Hülsing, Thomas;  Oltmann, Hergen;  Schmitz, Burkhard;  Hemmersbach, Ruth;  Grimm, Daniela 

Alterations of the cytoskeleton in human cells in space proved by life-cell imaging
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 6.2016, Art.-Nr. 20043, insges. 14 S.

Corydon, Thomas J.;  Mann, Vivek;  Slumstrup, Lasse;  Kopp, Sascha;  Sahana, Jayashree;  Askou, Anne Louise;  Magnusson, Nils E.;  Echegoyen, David;  Bek, Toke;  Sundaresan, Alamelu;  Riwaldt, Stefan;  Bauer, Johann;  Infanger, Manfred;  Grimm, Daniela 

Reduced expression of cytoskeletal and extracellular matrix genes in human adult retinal pigment epithelium cells exposed to simulated microgravity
In: Cellular physiology and biochemistry - Düsseldorf: Cell Physiol Biochem Press GmbH & Co KG, 1991, Bd. 40.2016, 1/2, S. 1-17

Frandsen, Sofie;  Kopp, Sascha;  Wehland, Markus;  Pietsch, Jessica;  Infanger, Manfred;  Grimm, Daniela 

Latest results for anti-angiogenic drugs in cancer treatment
In: Current pharmaceutical design - Hilversum: Bentham Science Publ, 2000, Bd. 22.2016, 39, S. 5927-5942

Kopp, Sascha;  Slumstrup, Lasse;  Corydon, Thomas J.;  Sahana, Jayashree;  Aleshcheva, Ganna;  Islam, Tawhidul;  Magnusson, Nils E.;  Wehland, Markus;  Bauer, Johann;  Infanger, Manfred;  Grimm, Daniela 

Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, 2011, Bd. 6.2016, Art.-Nr. 26887, insges. 18 S.

Laursen, Rasmus;  Wehland, Markus;  Kopp, Sascha;  Pietsch, Jessica;  Infanger, Manfred;  Grosse, Jirka;  Grimm, Daniela 

Effects and role of multikinase inhibitors in thyroid cancer
In: Current pharmaceutical design - Hilversum: Bentham Science Publ, 2000, Bd. 22.2016, 39, S. 5915-5926

Riwaldt, Stefan;  Bauer, Johann;  Wehland, Markus;  Slumstrup, Lasse;  Kopp, Sascha;  Warnke, Elisabeth;  Dittrich, Anita;  Magnusson, Nils E.;  Pietsch, Jessica;  Corydon, Thomas J.;  Infanger, Manfred;  Grimm, Daniela 

Pathways regulating spheroid formation of human follicular thyroid cancer cells under simulated microgravity conditions - A genetic approach
In: International journal of molecular sciences - Basel: Molecular Diversity Preservation International, 2000, Bd. 17 (2016), 4, Art.-Nr. 528, insges. 20 S.

Warnke, Elisabeth;  Kopp, Sascha;  Wehland, Markus;  Hemmersbach, Ruth;  Bauer, Johann;  Pietsch, Jessica;  Infanger, Manfred;  Grimm, Daniela 

Thyroid cells exposed to simulated microgravity conditions - comparison of the fast rotating clinostat and the random positioning machine
In: Microgravity science and technology - Heidelberg: Springer, 2007, Bd. 28.2016, 3, S. 247-260

2015

Begutachteter Zeitschriftenartikel

Kopp, Sascha;  Warnke, Elisabeth;  Wehland, Markus;  Aleshcheva, Ganna;  Magnusson, Nils E.;  Hemmersbach, Ruth;  Corydon, Thomas Juhl;  Bauer, Johann;  Infanger, Manfred;  Grimm, Daniela 

Mechanisms of three-dimensional growth of thyroid cells during long-term simulated microgravity
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 5.2015, Art.-Nr. 16691, insges. 17 S.

Svejgaard, Benjamin;  Wehland, Markus;  Ma, Xiao;  Kopp, Sascha;  Sahana, Jayashree;  Warnke, Elisabeth;  Aleshcheva, Ganna;  Hemmersbach, Ruth;  Hauslage, Jens;  Grosse, Jirka;  Bauer, Johann;  Corydon, Thomas Juhl;  Islam, Tawhidul;  Infanger, Manfred;  Grimm, Daniela 

Common effects on cancer cells exerted by a random positioning machine and a 2D clinostat
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 10.2015, 8, Art. e0135157, insges. 22 S.

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